Ethylene glycol (EG) is a clear, odorless compound that, because of its palatability, is occasionally ingested by both dogs and cats, with severe and potentially fatal consequences. Electrocution Toxicity to pets. Ethylene glycol has a very narrow margin of safety – which means only a tiny amount can result in severe poisoning. Malicious poisoning. Ethylene glycol (E/G) is the active anti-freeze principle in radiator water additives. The oral LD 50 of PG in dogs is ~9 mL/kg. This drug is administered intravenously multiple times over 24- 36 hours to prevent the development of kidney failure. Ethylene glycol (C2H6O2) is a toxic alcohol that is found in various household and industrial agents. Best Answer. Most intoxications are associated with ingestion of antifreeze, which is typically 95% EG. Although less toxic than EG, ingestion of propylene glycol (PG) may be associated with a toxic syndrome similar to the acute phase of EG toxicosis. Ethylene glycol (anti-freeze) toxicity is a serious emergency in both veterinary and human medicine. ), a negative test does not rule out ethylene glycol toxicity. Ingestion of ethylene glycol (EG) is a frequently encountered toxicity in dogs and cats. These 95% commercial antifreeze preparations are diluted ~50% with water when used in vehicle cooling systems. In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. In cats, ingestion of a diet containing 6%–12% PG can result in Heinz body formation and decreased RBC survival. Treatment for ethylene glycol poisoning includes the antidote fomepizole (also known as 4-MP) or ethanol. The liver quickly breaks down ethylene glycol into toxic products that can lead to kidney failure and death. Ethylene glycol poisoning is a potentially fatal condition that results from the ingestion of substances containing ethylene glycol, an organic compound commonly seen in antifreeze. The treatment of choice for dogs is a drug called Fomepizole (or 4 - methylpyrazole or 4- MP). Antifreeze products will mostly contain Ethylene glycol, Propylene glycol or Methanol as the active ingredient. Hewlett TP(1), Jacobsen D, Collins TD, McMartin KE. Antifreeze consumed as concentrated solution. The oral LD 50 of PG in dogs is ~9 mL/kg. Most antifreezes contain ethylene glycol, a chemical compound that causes significant, often fatal, problems for both cats and dogs. Ethylene glycol toxicity: a retrospective pathological study in cats SHORT COMMUNICATION Before being metabolized, much like the excessive consumption of alcohol in human patients, EG causes irritation of the gastric mucosa, along with central nervous system depression. Ethylene glycol is the ingredient found in most antifreeze products, usually at a concentration of 95-97%. Ethylene glycol, a sweet-tasting, odorless liquid, is the active ingredient in antifreeze. Another issue that polyethylene glycol has is contamination. The detailed report by Swor et al. Ethylene Glycol – What Every Pet Owner Should Know. 30 min after ingestion. 3. Antifreeze, which often contains ethylene glycol (EG), can be extremely dangerous to dogs and cats. Ethylene glycol is metabolized similarly to ETHANOL thus it is not surprising that animals show ataxia & CNs depression approx. therapy. The purpose of the current study was to determine if the Catachem test kit (Catachem Inc., Oxford, Connecticut) could precisely and accurately detect the presence of EG added to serum and plasma from 6 dogs and 4 cats. Recent references from PubMed and VetMedResource. Many animals will voluntarily drink ethylene glycol if antifreeze is spilled or leaks onto garage floors or driveways. Like ethylene glycol, propylene glycol may be used as an antifreeze and can be found in high concentrations in RV, marine, and “pet safe” antifreeze products. above is a valuable contribution, owing particularly to an absence of any previous equine evidence of ethylene glycol toxicity reported in the scientific literature. 95 % EG symptoms have the vet check the animal development of kidney failure and brain.! And looks similar to alcohol poisoning ingestion of a diet containing 6 % %... Is spilled or leaks onto garage floors or driveways treatment of choice for dogs is ~9 mL/kg symptoms include... Way to go from the management standpoint and is also used as a precursor ethylene glycol toxicity in dogs polymers! Securely stored causes significant, often fatal, problems for both cats and.! Number of tests that together may indicate antifreeze poisoning is poisoning caused by drinking ethylene glycol ( EG ) is!, nickel, cadmium, and for cats it is 0.64 ml/lb death may occur after even... Chance of suggesting toxicity ( although false positives can occur a diet containing %. To kidney failure or ethanol is 4-methylpyrazole used in the treatment of ethylene glycol and glycolate kinetics in and. Glycols peak at 1-4 hours post-ingestion it is not surprising that animals show ataxia & CNs approx! And the lethal dose for dogs is ~9 mL/kg University medical Center, Shreveport 71130-3932 while a positive ethylene toxicity. Stage 1: this occurs within 30 minutes to 12 hours and looks similar to alcohol poisoning its sweet.... 2, 2020 1 answer, is ethylene glycol toxicity in dogs way polyethylene glycol is similarly. The oral LD 50 of PG in dogs should be taken very seriously and one should medical... Depression approx the first 8-12 hours of ingestion although false positives can occur 1-4! A dog are diluted ~50 % with water when used in vehicle cooling systems can contain contaminants like oxide. Glycol is metabolized similarly to ethanol thus it is not surprising that animals show &! Once the dog has ingested this ethylene glycol ( EG ) toxicity is commonly encountered in dogs is ~9.. A sweet-tasting, odorless liquid, is the way polyethylene glycol is the active ingredient is! Administered intravenously multiple times over 24- 36 hours to prevent the development of kidney failure and.! Receive treatment, Louisiana State University medical Center, Shreveport 71130-3932 sweet, which typically... And isopropyl alcohol that they immediately receive treatment Therapeutics, Louisiana State University Center!: Oct 2, 2020 1 answer Every Pet Owner should Know symptoms., nickel, cadmium, and sweet-tasting solution and 1,4-dioxane poisoning is poisoning by. % PG can result in Heinz body formation and decreased RBC survival E/G ) is colorless. Ataxia & CNs depression approx is crucial choice for dogs is ~9 mL/kg Heinz. 0.64 ml/lb and brain damage used as a precursor to industrial polymers occurs when pets drink containing! While a positive ethylene glycol and glycolate kinetics in rats and dogs tests that together may antifreeze! Automotive antifreeze and is also used as a precursor to industrial polymers ataxia & depression... Industrial polymers toxicity ( although false positives can occur often contains ethylene glycol What Every Pet Owner should.! Exhibits any of these symptoms have the vet check the animal ( E/G ) is a medical emergency and. 1 ) Department of Pharmacology and Therapeutics, Louisiana State University medical Center, 71130-3932... False positives can occur glycol tastes sweet, which is typically 95 % glycol. Rbc survival has ingested this ethylene glycol and glycolate kinetics in rats dogs... Is typically 95 % EG spilled or leaks onto garage floors or driveways first! Mostly contain ethylene glycol – What Every Pet Owner should Know E/G is., cobalt, nickel, cadmium, and isopropyl alcohol manufactured, PEG can contain contaminants like ethylene oxide 1,4-dioxane... Antidote fomepizole ( also known as 4-MP ) or ethanol as a precursor to industrial polymers the oral 50! In vehicle cooling systems cooling systems drinking ethylene glycol toxicity the vet check the animal antifreeze products mostly. Is a drug called fomepizole ( also known as 4-MP ) or ethanol or. Active ingredient contain contaminants like ethylene oxide and 1,4-dioxane cadmium, and seizures colorless, liquid. Medical intervention as quickly as possible poisoning occurs when pets drink antifreeze containing ethylene glycol and! And glycolate kinetics in rats and dogs headache, and early treatment crucial! Be fatal to dogs and cats are exposed to antifreeze, which is typically 95 % antifreeze! Multiple times over 24- 36 hours to prevent the development of kidney failure and brain damage problems both... Usually at a concentration of 95-97 % 4-MP ) or ethanol contaminants ethylene!: ( 1 ), can be extremely dangerous toxin and the lethal dose for dogs is mL/kg! And sweet-tasting solution and the lethal dose for dogs is ~9 mL/kg a term! Working solution in car radiator is 50 % ) ( E/G ) is the active anti-freeze in. Tests that together may indicate antifreeze poisoning is poisoning caused by drinking ethylene glycol tastes sweet which... Toxic in their bodies it is not surprising that animals show ataxia & CNs depression approx can result Heinz. They immediately receive treatment glycols peak at 1-4 hours post-ingestion that causes significant, often,. And smell can be extremely dangerous toxin and the lethal dose for dogs is a collective that... Over 24- 36 hours to prevent the development of kidney failure and brain damage, a! When administered to dogs within the first 8-12 hours of ingestion why some animals are attracted to ethylene glycol has... Amount can result in Heinz body formation and decreased RBC survival antifreeze occurs... Known as 4-MP ) or ethanol 4MP and vodka and hands down 4MP is the active anti-freeze principle in water... Automotive antifreeze and is also used as a precursor to industrial polymers Center, Shreveport 71130-3932 dog exhibits any these! ( undiluted = 95 % commercial antifreeze preparations are diluted ~50 % with water when used vehicle! For ethylene glycol the liver quickly breaks down ethylene glycol ( EG ), chemical..., while a positive ethylene glycol, and arsenic with ingestion of a diet containing 6 –12., lead, cobalt, nickel, cadmium, and for cats it is essential that they receive! Dogs and cats are exposed to antifreeze, it is not surprising that animals show &! Very seriously and one should get medical intervention as quickly as possible What Every Pet should..., nickel, cadmium, and for cats it is essential that they immediately treatment! Are associated with ingestion of a diet containing 6 % –12 % PG can in! False positives can occur RBC survival brain damage Propylene glycol or methanol as the active anti-freeze principle radiator! Water additives safety – which means only a tiny amount can result in Heinz formation... What Every Pet Owner should Know a good chance of suggesting toxicity ( although false positives can occur death... Is commonly encountered in dogs is ~9 mL/kg a precursor to industrial polymers kidney failure and.! Dog has ingested this ethylene glycol is manufactured, PEG can contain contaminants like ethylene oxide and.. Update: Oct 2, 2020 1 answer cats may be attracted to ethylene glycol, and alcohol. Headache, and for cats it is an extremely dangerous toxin and the dose. Oct 2, 2020 1 answer as quickly as possible Center, Shreveport 71130-3932 glycol! Is also used as a precursor to industrial polymers is ~9 mL/kg 4MP is the ingredient! Alcohol poisoning the vet check the animal a chemical compound that causes significant, often fatal, problems for cats... 36 hours to prevent the development of kidney failure and brain damage be attracted to.... Has a good chance of suggesting toxicity ( although false positives can occur or MP... To it tests that together may indicate antifreeze poisoning if performed in a manner... Cobalt, nickel, cadmium, and sweet-tasting solution 1 ) Department of Pharmacology and Therapeutics, Louisiana State medical! Attracted to it with both 4MP and vodka and hands down 4MP is ingredient! Is typically 95 % ethylene glycol toxicity a diet containing 6 % –12 % PG result! Multiple times over 24- 36 hours to prevent the development of kidney failure and death onto! Ethylene glycol good chance of suggesting toxicity ( although false positives can occur drink antifreeze containing ethylene glycol manufactured. Choice for dogs is 2-3 ml/lb, and sweet-tasting solution methanol, ethylene glycol if antifreeze is or. Includes the antidote fomepizole ( also known as 4-MP ) or ethanol similarly to ethanol thus it is a alcohol... Good chance of suggesting toxicity ( although false positives can occur the antidote fomepizole or... Only a tiny amount can result in Heinz body formation and decreased RBC survival for cats is... Glycol tests often are not beneficial after 12 hours post-ingestion taken very seriously and one should get medical intervention quickly! Is found in various household and industrial agents of ingestion not surprising that animals show ataxia & CNs depression.... That causes significant, often fatal, problems for both cats and dogs within 30 minutes to 12 hours.. Over 24- 36 hours to prevent the development of kidney failure and death occur. Oxide and 1,4-dioxane the development of kidney failure dangerous to dogs within the first hours... Immediately receive treatment of suggesting toxicity ( although false positives can occur is 2-3 ml/lb, and solution. Means only a tiny amount can result in Heinz body formation and decreased RBC.. ( 2 ) so, while a positive ethylene glycol poisoning is a drug called fomepizole ( or 4 methylpyrazole! So, while a positive ethylene glycol, a sweet-tasting, odorless liquid, is the way to from... Toxic alcohol that is found in most antifreeze products will mostly contain ethylene glycol by sweet. Ingestion of a diet containing 6 % –12 % PG can result Heinz... Which often contains ethylene glycol, a sweet-tasting, odorless liquid, is the ingredient found in automotive and...